Cerezyme: Side effects, precaution, Indication

Genzyme | Cerezyme (Medication)

Cerezyme: Indications

Cerezyme is used to treat Gaucher disease long term. Gaucher disease is a rare hereditary disorder, characterized by a deficiency of an enzyme called glucocerebrosidase, which breaks down, usually a fatty waste product called glucocerebroside. Without this enzyme, glucocerebroside accumulate in the body, usually the liver, spleen and bone marrow, causing symptoms: anemia (low red blood cells), fatigue, easy bruising and bleeding tendency, enlarged spleen and liver , bone pain and fractures. Cerezyme is used in patients who have type 1 Gaucher disease, which affects nerve cells, or type 3, which affects nerve cells over long periods of time. Patients must have symptoms that do not affect the nervous system, including one or more of the following conditions: – anemia, – thrombocytopenia (low platelet count in blood) – bone disease – enlarged liver or spleen enlargement. The medicine can only prescription….

Cerezyme: Side Effects

The most common side effects with Cerezyme are respiratory symptoms (breathlessness), urticaria (skin blisters) or angioedema (swelling under the skin), pruritus (itching) and rash. Patients may develop antibodies (proteins produced in response to Cerezyme and can affect treatment) and should be monitored for any reactions to the discovery of Cerezyme during the first year of treatment….

Cerezyme: Precaution

Cerezyme is administered with caution in people who may be hypersensitive (allergic) to imiglucerase or any other ingredients.

Pulmonary hypertension and pneumonia are known complications of Gaucher disease and have been observed both in patients receiving and not receiving Cerezyme (imiglucerase). No causal relationship with Cerezyme (imiglucerase) has been established. Patients with respiratory symptoms in the absence of fever should be evaluated for the presence of pulmonary hypertension.

Therapy with Cerezyme/imiglucerase should be directed by physicians knowledgeable in the management of patients with Gaucher disease. Caution may be advisable in administration of Cerezyme/imiglucerase) to patients previously treated with Ceredase (alglucerase injection).

Studies have not been conducted in either animals or humans to assess the potential effects of Cerezyme/imiglucerase for injection on carcinogenesis, mutagenesis, or impairment of fertility.

During pregnancy and breastfeeding is not recommended to use this medicine without your doctor advice….

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