Pharmacia Limited | Cox – 2 (Cyclooxygenase) Inhibitors (Medication)
Cox – 2 (Cyclooxygenase) Inhibitors: Indications
COX-2 inhibitors are used for treating conditions that cause inflammation, mild to moderate pain, and fever. COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). Prostaglandins also protect the lining of the stomach and intestines from the damaging effects of acid, promote blood clotting by activating platelets, and also affect kidney function. Unlike aspirin, also an NSAID, they are not effective for preventing strokes and heart attacks in individuals at high risk for such events….
Cox – 2 (Cyclooxygenase) Inhibitors: Side Effects
Most common side effects include: abdominal pain, insomnia, flatulence (gas), diarrhea, nausea, and headache.
COX-2 inhibitors and other NSAIDs may increase the risk of heart attacks, stroke, and related conditions, which can be fatal. This risk may increase with duration of use and in patients who have underlying risk factors for disease of the heart and blood vessels.
People allergic to sulfonamides, for example, trimethoprim (Trimpex, Proloprim, Primsol) and sulfamethoxazole (Bactrim), aspirin or other NSAIDs may experience allergic reactions to COX-2 inhibitors and should not take them….
Cox – 2 (Cyclooxygenase) Inhibitors: Precaution
Prior to using COX-2 inhibitors tell your healthcare provider if you have any type of allergies. Concomitant use of celecoxib with aspirin or other NSAIDs may increase the occurrence of stomach and intestinal ulcers. It may be used with low dose aspirin.
Alcohol consumption increases the risk of developing stomach ulcers when taking NSAIDs; this may also apply to celecoxib.
During pregnancy and breastfeeding is not recommended to use this medicine without your doctor’s advice….