Diphenoxylate and atropine: Side effects, precaution, Indication

Valeant Pharmaceuticals International | Diphenoxylate and atropine (Medication)

Diphenoxylate and atropine: Indications

Diphenoxylate and atropine is a combination medication used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. It should not be used in children.

Diphenoxylate comes as a tablet and solution (liquid) to take by mouth. It is usually taken as needed up to 4 times a day. Follow the directions on your prescription label carefully….

Diphenoxylate and atropine: Side Effects

The most common side effects reported in persons taking diphenoxylate include drowsiness, headache, nausea or vomiting, and dry mouth. Euphoria, depression, lethargy, restlessness, numbness of extremities, loss of appetite, and abdominal pain or discomfort have been reported less frequently.

Although the dose of atropine in Lomotil is too low to cause side effects when taken in the recommended doses, side effects of atropine (including dryness of the skin and mucous membranes, increased heart rate, urinary retention, and increased body temperature) have been reported, particularly in children under two years of age and children with Down syndrome. Pancreatitis and toxic megacolon also have been reported.Drowsiness, dizziness, headache, tiredness, blurred vision, dry mouth, and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Many people using this medication do not have serious side effects.
Tell your doctor immediately if any of these unlikely but serious side effects occur: stomach/abdominal pain or swelling, severe nausea, vomiting, mental/mood changes (e.g., confusion, depression), restlessness, numbness/tingling of arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing….

Diphenoxylate and atropine: Precaution

Before using this medicine inform your doctor if you have any type of allergies. Tell your doctor if you are using other medicine and if you have or ever have had any of the following conditions: kidney disease, colitis, or stomach problems.

Taking diphenoxylate with alcohol or other chemicals or medications that can depress the central nervous system may cause excessive sedation. Such drugs include barbiturates, benzodiazepines, for example, lorazepam, diazepam, temazepam, oxazepam or clonazepam, zolpidem, narcotics, and tricyclic antidepressants….

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